a-Amino acids are important targets for the medicinal and biotechnology fields and their optical purity is an important factor in biological activity. In the early 1980s Schöllkopf developed a method to produce optically pure a-amino acids that involved diastereoselective alkylation of a masked glycine.1
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (product code FD03725) is now known as a Schöllkopf chiral auxiliary.
1. Deng C, Groth U, Schöllkopf U, Angew. Chem. Int. Ed. 1981, 21, 798