Availability
0
Your Basket is Empty
BO168359
BIO-X

O151 NEW

Selective and potent inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.6 μM. OGG1 is a key enzyme in DNA repair mechanism called base excision repair (BER). The compound inhibits the hydrolysis of glycosidic bond required for the excision of 8-oxoguanine from double stranded DNA, which leads to accumulation of mutations. It has been proposed as monotherapy for certain types of cancers as well as adjuvant for cancer therapy with DNA damaging agents. It has potential to sensitize tumours for chemotherapy and inhibit development of drug resistance mechanisms.

Technical Data

CAS No: 304478-23-7
Synonyms: 2-Cyclohexylidenehydrazide-4-bromobenzoic acid
Product Code: BO168359
Chemical Formula: C13H15BrN2O
Molecular Weight: 295.18

References


  • Poletto et al. (2017). DNA Base Excision Repair: The Achilles’ Heel of Tumour Cells and their Microenvironment? Current Pharmaceutical Design 23:4758-4772.
  • Donley et al. (2015). Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chemical Biology 10(10):2334-2343.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
304478-23-7
Synonyms:
2-Cyclohexylidenehydrazide-4-bromobenzoic acid
Chemical Formula:
Molecular Weight:
295.18
Product Structure
References:
1. Poletto et al. (2017). DNA Base Excision Repair: The Achilles’ Heel of Tumour Cells and their Microenvironment? Current Pharmaceutical Design 23:4758-4772.
2. Donley et al. (2015). Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chemical Biology 10(10):2334-2343.
Click for Specification
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...