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DNA Cross Linkers

These compounds cause DNA interstrand crosslinks that include natural alkylating agents such as mitomycin C or synthetic agents, such as platinum compounds. These DNA lesions, if left unrepaired, lead to disruption of DNA replication and transcription and therefore have genotoxic and cytotoxic consequences. DNA cross linkers thus have therapeutic applications in treating solid tumors, as well as autoimmune diseases and dermatological conditions. The DNA cross linkers available from Carbosynth are listed below.

Code Cas No Product Description
BB164239 3543-75-7

Bendamustine hydrochloride

DNA alkylator; purine analog BIO-X
BC164284 41575-94-4

Carboplatin

Platinum-based anti-cancer agent
BC164289 154-93-8

Carmustine

DNA alkylating agent; antineolplastic BIO-X
BC164315 15663-27-1

Cisplatin

Platinum-based anti-cancer agent; pro-apoptotic
FE22772 146665-77-2

Eptaplatin

Platinum-based anti-tumor drug BIO-X
FE37343 2998-57-4

Estramustine

DNA-alkylating agent; anti-cancer agent; estradiol derivative
FI24535 57852-57-0

Idarubicin hydrochloride

Topoisomerase II inhibitor; daunorubicin analog; anti-leukemic; anthracycline BIO-X
BI166243 3778-73-2

Ifosfamide

Alkylating agent; anti-cancer agent
BL164634 13010-47-4

Lomustine

Alkylating agent; chemotherapeutic agent BIO-X
FB25047 148-82-3

Melphalan

Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent
BM164668 50-07-7

Mitomycin C

Chemoterapeutic agent; DNA crosslinker BIO-X
FM61451 70476-82-3

Mitoxantrone hydrochloride

Inhibits DNA topoisomerase II; antineoplastic; immunomodulatory; antimicrobial BIO-X
BN164659 55661-38-6

Nimustine hydrochloride

Antineoplastic; DNA alkylating agent
FP65121 31645-39-3

Palifosfamide

Active metabolite of ifosfamide; alkylates and cross-links DNA; antineoplastic BIO-X
FP65130 181630-15-9

Picoplatin

Platinum-based anti-cancer agent; induces apoptosis BIO-X
FP158112 202350-68-3

PNU 159682

DNA alkylating agent; highly potent metabolite of nemorubicin
BP164298 366-70-1

Procarbazine hydrochloride

Anti-cancer alkylating agent; inhibits protein, RNA and DNA synthesis
FR55382 58994-96-0

Ranimustine

Anti-cancer; inhibits proliferation of cancer cells by DNA cross-linking
FS65158 129580-63-8

Satraplatin

Platinum-based chemotherapeutic agent BIO-X
Q-201786 85622-93-1

Temozolomide

BT164447 85622-93-1

Temozolomide

DNA methylating agent; anti-tumorigenic; anti-angiogenic BIO-X
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