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Coupling Agents

Coupling agents are widely used for amide and ester formation, especially for solid-phase peptide synthesis, as they facilitate bond formation without becoming part of the linkage. In synthetic organic chemistry, compounds containing the carbodiimide functionality act as dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. Additives, such as N-hydroxybenzotriazole or N-hydroxysuccinimide, are often added to increase yields and decrease side reactions.

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Code Cas No Product Description
FB15685 164298-25-3

BTFFH

Peptide coupling reagent
FB45526 1433-27-8

1-(tert-Butyl)-3-ethylcarbodiimide

FC02706 530-62-1

N,N'-Carbonyl diimidazole

FC19968 37091-73-9

2-Chloro-1,3-dimethylimidazolinium chloride

FC15427 1075198-30-9

4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate

Coupling agent in phosphonamidation and synthesis of solid phase peptides
FC55888 2491-17-0

N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate

Water-soluble condensing reagent for peptide synthesis
FD05508 538-75-0

1,3-Dicyclohexyl carbodiimide

FD02073 693-13-0

1,3-Diisopropylcarbodiimide

Used for synthesis of organic compounds, peptides and nucleic acids
FD02693 1892-57-5

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

FD05800 25952-53-8

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl

Coupling agent; carboxyl activating agent; used in immunoconjugates
FD03847 22572-40-3

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide methiodide

FH09243 148893-10-1

HATU

Additive in peptide synthesis
FH07095 94790-37-1

HBTU

FH15560 330645-87-9

HCTU

FT07096 125700-67-6

TBTU

FT09614 2564-83-2

2,2,6,6-Tetramethylpiperidine 1-oxyl, free radical - free flowing milled solid

Catalytic oxidant
FT04400 2564-83-2

2,2,6,6-Tetramethylpiperidine 1-oxyl, free radical - solid melt

Catalytic oxidant
FT45365 61881-19-4

2,2,2-Trifluoro-N-phenylacetimidoyl chloride

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