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Kavalactones are a class of lactone compounds found in the kava shrub. At least 18 different kavalactones have been identified to date, with methysticin being the first identified. Multiple analogues, such as ethysticin, have also been isolated. Some consist of a substituted α-pyrone as the lactone while others are partially saturated. Kava extract has been shown to potently inhibit a wide range of hepatic enzymes, suggesting a very high potential for interactions with many pharmaceuticals and herbal medications. There is also evidence of kavalactones having various psychotropic effects, including anxiolytic and sedative activities.


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